|
Home > Under Spotlight
Granules For Oral Suspension - Sachet Formulations
Clesstra Healthcare Pvt. Ltd, is one of the few manufacturers and Suppliers of granules for Oral
Suspension, and supplies them in single dose sachets made of 4 layered aluminium foils.
A number of official and commercial preparations are available as dry powder mixtures or granules that
are intended to be suspended in water or some other vehicle prior to oral administration.
Most of the drugs prepared as a dry mix for oral suspension are antibiotics. The dry mix of oral
suspension is prepared commercially to contain the drug, colorants, flavourants, sweeteners,
stabilizing agents, suspending agents and preserving agents that may be need to enhance the stability of
the formulation.
The granules in the sachets must be taken as a suspension in a glass containing prescribed amount of
ingestible liquid, mostly water.
Although studies have demonstrated that the dry oral suspension after constitution in a liquid is stable
for 24 hours after preparation, it is recommended that the suspension should be consumed immediately
after preparation.
Major Application - Pediatric therapy: Taste masking
Oral Route of administration is the route of choice for administration of medicines in children.
The only hurdle for dosage form designing for pediatric patients is the patient’s acceptance of the
dosage form. Pediatric Patients tend to become un-co-operative during the administration of oral
medication; the most common reason being the taste of the oral formulation administered among the
children.
Most of the drugs administered as granules for granules for oral suspension under pediatric
therapyare Antibiotics, which when administered orally as any other dosage form have a bitter taste
making it unpleasant for Children to consume the medication.
The solution for this is Taste masking and the major application of taste masking can be observed in
Granules for oral suspension.
Top
Dry Oral Suspensions Advantages Over Liquid Oral Suspensions:
Disadvantages of liquid oral suspensions include:
- Bulk formulation- inaccurate single dosing
- Drug Dose dependent on various physical factors of the dosage form including:
- Temperature of storage
- Sedimentation rate of the formulation
- Liquid flow properties-viscosity, pourability, redispersion, flocculation
- Content uniformity
- Stability of the liquid suspension largely depends on the temperature of storage
- Caking upon storage
- For patients- administration is inconvenient
Advantages of Dry Granules for oral suspension:
- Accurate single dosing: Single dose sachets
- Drug dose is comparatively independent of any physical factors i.e. temperature,
sedimentation rate and liquid flow properties
- Sachets: 4 layered aluminium foils making the formulation extremely stable and convenient
to carry.
- Enhanced convenience of single dosage regimen.
- Coloured, flavoured, sweet to taste formulation administration among pediatric patients.
- Palatable and widely accepted in Pediatric patients all over the world.
- Stability: Stable on storage and when constituted with an ingestible liquid for
administration, the corresponding liquid suspension is stable for the duration in which the
therapy is required.
Top
References:
Modern pharmaceutics, Volume 121
By Gilbert S. Banker, Christopher T. Rhodes
Ansel's pharmaceutical dosage forms and drug delivery systems
By Loyd V. Allen, Nicholas G. Popovich, Howard C. Ansel
Top
|
|
|
|
|
